My PC chassis uses sliding drive rails to mount drives. Can I attach these rails to your hard drive solutions?

Yes, there should be no problem attaching any of our hard drive solutions to drive rails. Just keep an eye on the temperature of the drive for the first day or so after installation, since heat dissipation from the solution into the chassis could be slightly reduced compared with mounting the product directly using screws. The Silentmaxx HDD enclosure may take up two 5.25" drive bays because the mounting holes may not align correctly. But it will connect without any problems.